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Основной контент книги ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins
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Book duration 479 pages

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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Applications in Drug Discovery and Development
Читайте только на Литрес

The book cannot be downloaded as a file, but can be read in our app or online on the website.

$182.87

About the book

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.

• Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain

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Book Honghui Zhou, Frank-Peter Theil «ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins» — read online on the website. Leave comments and reviews, vote for your favorites.
Age restriction:
0+
Release date on Litres:
05 July 2018
Volume:
479 p.
ISBN:
9781118898802
Total size:
21 МБ
Total number of pages:
479
Publisher:
Copyright holder:
John Wiley & Sons Limited
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